A systemic chronic autoimmune spondyloarthropathy characterized by -
Causes - there is a genetic predisposition, but mode of inheritance is unknown. HLA-B27 is located on the sixth chromosome, B locus.
Lumbosacral pain and stiffness
Neck and upper thoracic pain
Sciatica- likely originates from sciatic nerve involvement in the pelvic (piriformis spasm)
loss of horizontal gaze.
shortness of breath - caused by costovertebral joint involvement, leading to reduced chest expansion.
Investigations - A thorough clinical examination by your clinician.